The World Health Organization (WHO) has announced the formation of a Guideline Development Group (GDG) dedicated to creating evidence-based recommendations on multiplex testing. This initiative aims to establish essential principles for integrated testing and address the most current evidence related to HIV, viral hepatitis, and sexually transmitted infections (STIs).
Timely and accurate diagnostic testing is crucial for the prevention, detection, and management of these health concerns, particularly in low- and middle-income countries. With health systems worldwide shifting towards integrated, people-centred service delivery models, multiplex testing emerges as a significant strategy. It promises to enhance efficiency, broaden testing coverage, and improve cost-effectiveness across various diseases.
Multiplex testing allows for the detection of multiple infections from a single sample and platform, streamlining the diagnostic process. The upcoming guidelines will be the first to incorporate the latest evidence and implementation strategies specifically addressing multiplex testing. While the primary focus will be on HIV, viral hepatitis, and STIs, these guidelines will outline critical integration principles that can drive public health impact and pave the way for future multi-disease testing approaches.
Upcoming Meetings and Objectives
The GDG will convene virtually, with an important meeting scheduled for 4-5 November 2025. The objective of these meetings is to provide comprehensive recommendations and guidance for health providers and self-testers. The discussions will also focus on establishing key principles for integration and addressing the challenge of prioritizing limited resources in order to maximize public health outcomes.
In line with WHO guidelines for developing recommendations, the GDG comprises members from all WHO regions. These professionals serve in their individual capacities, not as representatives of affiliated organizations. WHO technical staff selected GDG members based on their expertise, their roles as end-users such as programme managers and healthcare providers, and their representation of affected communities. Notably, members do not receive financial compensation for their contributions to this initiative.
To promote transparency and inclusivity, WHO invites the public and interested organizations to review the biographies of GDG members. This approach underscores the commitment to establishing guidelines that are reflective of diverse perspectives and expertise.
The development of these guidelines is a pivotal step in enhancing diagnostic testing frameworks, particularly in resource-constrained settings. By leveraging multiplex testing, WHO aims to facilitate earlier detection and better management of HIV, viral hepatitis, and STIs, ultimately contributing to improved health outcomes globally.
