When Jayden McKinnon graduated from high school, he envisioned a career in medicine, driven by his passion for sports and an innate curiosity about the human body. However, guidance from school advisers suggested he pursue a trade instead, leading him to reconsider his path. This advice acted as a catalyst, propelling him toward a career in one of science’s most complex fields: motor neurone disease (MND) research.
Jayden’s journey to becoming a researcher was unconventional. He openly admits that science was not his strongest subject during his school years. Undeterred, he delved into a Biology for Dummies textbook, dedicating a year to self-study. His perseverance paid off when he secured early admission to the University of Wollongong (UOW) to pursue a science degree. Today, he is immersed in a PhD program in analytical biochemistry at UOW’s Molecular Horizons.
At the heart of Jayden’s research is the use of advanced mass spectrometry imaging to explore how lipids and fats contribute to the development of MND, a devastating neurodegenerative disorder. He approaches this intricate research with enthusiasm, excitedly discussing the complex questions he seeks to answer. “I love it so much. I’m always thinking about it,” he states. “It feels like a hobby, and somehow I get paid to do it.”
Innovative Research in the Yerbury Lab
Within UOW’s Yerbury Lab, Jayden’s innovative mindset shines. His focus on visualising lipid alterations in spinal cord tissue allows him to investigate changes at the level of individual motor neurons. This work, conducted alongside a team of distinguished scientists, aims to unravel the mysteries surrounding MND.
Dr. Jeremy Lum, an MND researcher and leader at the lab since the passing of renowned scientist Professor Justin Yerbury in 2023, commends Jayden’s curiosity and creativity. “Jayden is one of the most curious young scientists I’ve worked with,” says Dr. Lum. “He is always coming up with new and innovative ideas, backed up with a can-do attitude.”
Utilising cutting-edge imaging technology, one of the few facilities globally capable of examining single cells in such detail, Jayden and his supervisors—Dr. Lum, Associate Professor Shane Ellis, and Professor Todd Mitchell—are mapping biological processes at an unprecedented resolution. “This unique imaging platform lets us see exactly what’s going wrong, when, and in which cell type,” he explains.
Understanding how lipids are dysregulated in motor neurons is crucial, as it may lead to identifying specific lipids that contribute to cell degeneration. This research could pave the way for new therapeutic targets in treating MND.
Driving Change in MND Treatment
Jayden’s ambitious research is driven by a desire to create impactful solutions. He emphasizes the need for a personalised approach to MND treatment, moving away from universal methods. “I love the challenge, I love solving problems with real-world impact,” he remarks. “Our aim is to drive a personalised way of looking at MND treatment, rather than a one-size-fits-all approach.”
Reflecting on his journey, Jayden acknowledges the significant contributions of those before him in the Yerbury Lab. Their groundbreaking work has laid the foundation for his current research, which holds promise for reshaping how scientists understand and treat MND.
As the University of Wollongong celebrates its 50th anniversary, the spotlight on MND research is particularly poignant. Jayden McKinnon’s story exemplifies the potential of determination and innovative thinking in science, inspiring the next generation of researchers to unlock the secrets of complex diseases like MND.
Through collaborative efforts and cutting-edge technology, the Yerbury Lab continues to be a beacon of hope in the fight against motor neurone disease, with Jayden McKinnon at the forefront of this critical research.
