UPDATE: CHANDO has just unveiled a revolutionary skin brightening research finding at the IMCAS World Congress in Paris, revealing a novel epigenetic mechanism specifically for Asian skin. This ground-breaking discovery, presented by CHANDO skin research scientist Dr. Youssef, highlights the company’s commitment to addressing unique skin challenges faced by Asian populations.
The congress, which took place from January 31 to February 7, 2026, is a pivotal event for aesthetic medicine, attracting over 21,764 professionals from around the globe. CHANDO’s presentation focused on the 4-Butylresorcinol (577) Pigment Management Mechanism, showcasing a decade of research aimed at understanding the biological factors influencing skin pigmentation in Asian individuals.
This urgent update is critical as it marks a significant leap in precision skincare, targeting persistent issues such as stubborn dark spots and the fragile skin barrier that often leads to rebound darkening. CHANDO’s research stands out by employing a targeted approach, utilizing high-throughput sequencing and bioinformatics to analyze how environmental factors, particularly UV exposure, affect gene expression in Asian skin.
Dr. Youssef emphasized that since 2014, CHANDO has identified a specific microRNA that regulates three vital enzymes involved in melanin production. This pivotal finding indicates that the company’s signature ingredient, 4-Butylresorcinol (577), effectively inhibits the abnormal expression of this microRNA, preventing melanin overproduction at its source.
In clinical trials, the ingredient demonstrated remarkable tolerability, making it ideal for sensitive skin types. Participants in a recent study reported a 21.47% reduction in skin melanin and a 34.92% improvement in brightness after using the Cellcrystal Whitening Radiance Rejuvenating Serum for just four weeks. These results showcase the immediate impact of CHANDO’s innovative approach to skin brightening.
This research not only underscores CHANDO’s role as a frontrunner in skincare innovation but also highlights the importance of international scientific collaboration. The recognition of CHANDO as the “Global 577 Brightening Leader” by the Shangpu Group adds further credibility to their findings, which are now contributing significantly to global skincare advancements.
As the skincare industry evolves, CHANDO is set to continue its investment in research, ensuring that its products remain at the forefront of scientific development. The implications of this breakthrough for consumers seeking effective and safe skin brightening solutions are profound, offering hope for many who struggle with pigmentation issues.
The world is watching as CHANDO leads the charge in redefining skincare through science. With ongoing research and development, the future of skin brightening looks more promising than ever. Stay tuned for more updates as CHANDO continues to push the boundaries of skincare innovation.
